NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body. It plays a vital role in producing energy, repairing cells, supporting tissue regeneration, and maintaining overall health. NAD⁺ is involved in over 500 enzyme reactions, including those related to DNA repair, immune function, and brain activity.
As we age, NAD⁺ levels naturally decline. This drop is linked to slower metabolism, fatigue, cognitive decline, and a higher risk of age-related conditions. To counter this, NAD⁺ boosters are being studied for their potential to improve energy and focus, support healthy aging, enhance muscle recovery, and protect against neurodegenerative conditions.
Several molecules have been identified as NAD⁺ precursors, which are compounds the body can convert into NAD⁺. Among these, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) — both forms of vitamin B3 — have shown strong clinical potential to efficiently raise NAD⁺ levels. Another precursor, the amino acid tryptophan, can also be converted into NAD⁺, though less efficiently due to its other roles in the body.
While NAD⁺ itself is available in supplement form, it’s chemically unstable and poorly absorbed, making NR and NMN more effective options for boosting NAD⁺ levels.
Why Nicotinamide Riboside (NR) Is The Best NAD⁺ Booster
Among the various NAD⁺ precursors, nicotinamide riboside (NR) has gained attention for its high bioavailability, meaning it’s easily absorbed and converted into NAD⁺ by the body. NR is a form of vitamin B3 that bypasses some of the slower metabolic steps required by other precursors like tryptophan or niacin.
Key Benefits of NR:
- Efficient NAD⁺ boost: NR has been shown in human studies to significantly raise NAD⁺ levels within hours of supplementation.
- Supports cellular energy: By increasing NAD⁺, NR helps fuel mitochondria, the energy-producing structures in your cells.
- Promotes healthy aging: Research suggests NR may improve markers of metabolic health, brain function, and muscle recovery.
- Well-tolerated: NR is generally safe with few reported side effects, even at higher doses.
NR vs NMN:
Both nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are popular NAD⁺ precursors, and both can help raise NAD⁺ levels in the body. But if you’re wondering which one has the edge, NR tends to be more widely studied and easier to absorb, especially in humans. It is also generally easier to find and more affordable than NMN.
For a long time, scientists believed that NMN needed to be converted into NR before entering cells. Recent research suggests NMN might have its own transport pathway — but this is still being explored. That means NR remains the more predictable and accessible option for now.
What to Look for in an Effective NAD⁺ Supplement
Given the right formula, from a quality manufacturer that has based their product upon scientific research and clinical data, there are NAD⁺ boosters that will work. In fact, there are already thousands of people living healthier lives thanks to NAD⁺ boosters. Our research shows that the right combination of ingredients can effectively support healthy NAD⁺ levels.
Due to its high bioavailability and the extensive research behind it, we recommend choosing an NAD⁺ Booster that is centered around NR. Clinical data found that 300mg of NR is effective for boosting NAD⁺ levels in as little as a week. Therefore, we recommend choosing a supplement with this amount per daily serving.
Second, we recommend looking for a product with supportive ingredients that contribute to NAD⁺ synthesis or maintenance. For example, Vitamin B2 plays a critical supporting role in NAD⁺ metabolism by helping convert dietary precursors (such as NR) into usable NAD⁺ within cells. While it doesn’t directly boost NAD⁺ levels, it’s an essential tool that helps protect the enzymes that make NAD⁺ work. Even if you’re taking NAD⁺ boosters like NR or NMN, low vitamin B2 levels could limit their effectiveness.
Additionally, an effective NAD⁺ booster should contain an antioxidant to protect the NAD⁺ inside of the cells. This is because it’s easier to boost NAD⁺ when it’s not being rapidly broken down inside the cells. For example, Quercetin inhibits an enzyme that breaks down NAD⁺ levels and thereby helps to preserve NAD⁺ levels. Other antioxidants such as Resveratrol, Curcumin, and Vitamin C are also popular, though Quercetin has the most direct impact on NAD⁺ levels.
When choosing an NAD⁺ supplement, you should look for a company with a strong reputation that sells a wide range of nutritional health supplements. If you come across a company selling NAD⁺ boosters using strong marketing terms or slogans, or if they are endorsed by famous celebrities, you should stay clear. If the company and product formula don’t speak for themselves, then nothing else should.
About Our Guide
If you’re considering an NAD⁺ booster and want to make an informed choice, our guide is here to help. We’ve reviewed a wide range of supplements currently on the market, evaluating each based on its ingredients, clinical support, consumer feedback, brand reputation, and overall value.
Our top recommendation stands out for its:
- Clinically backed formula utilizing NR
- Transparent labeling and third-party testing
- Excellent customer reviews and satisfaction
- Generous money-back guarantee
We believe this product offers one of the most effective and trustworthy options for boosting NAD⁺ levels — and we think you’ll agree. Explore our full reviews to find the supplement that best fits your goals and lifestyle.
NAD+ Booster Report
APPROVED
Rating: Excellent
✓ Effectiveness
✓ Potency
✓ Money Back Guarantee
✓ Value
✓ Consumer Feedback
✓ Company Reputation
|
Editor’s Choice
Approved Science NAD+ Booster
If you are looking to support your longevity, age healthfully, and improve your daily vitality, then Approved Science NAD+ Booster is something that deserves your undivided attention. Of all the NAD+ support supplements currently available on the market, this is the one that deserves a closer look and very likely the one that will make a real difference to your health.
It contains NR-Sci™ Complex with a clinically studied dosage of 300mg NR, the most studied NAD+ precursor. It was the only product we found that contains vitamin B2 for supporting the conversion of NR into NAD+. We also like that it includes Quercetin for protecting and maintaining NAD+ levels inside the cells. In addition, it contains BioPerine®, which is a bioavailability enhancer to boost nutrient absorption. It does not contain any harmful additives or preservatives and only uses third-party tested ingredients.
Quality: Approved Science NAD+ Booster contains high-grade, natural, clinically-verified ingredients and is manufactured in a GMP-certified and FDA-registered facility.
Reputation: Their reputation is top quality. This manufacturer has several third-party monitoring services, including buySAFE, Norton, and Trustee, as well as an A+ rating from the quality monitoring company QualityTrusted.
Money-Back Guarantee: Every item sold is supported by a 60-day 100% money-back guarantee. Such guarantees from manufacturers show strong confidence in their products’ ability to deliver results. Great news for consumers!
Additionally, they are well known in the industry and an established company that provides great customer support service, secure and easy checkout as well as prompt, efficient delivery.
If you are looking for a product that ticks all the boxes for an effective NAD+ booster, from an established reputable company with an excellent money-back guarantee, this is the supplement for you.
It would be good to note that, due to high demand, Approved Science NAD+ Booster may occasionally go out of stock. To avoid having to back order, don’t hesitate to make that purchase when you see it in stock.
See The Full Review
|
| |
|
Rating: Good
|
TOPCAPAK Liposomal NAD+
Marketed as a skin aging support supplement for boosting NAD+, TOPCAPAK Liposomal NAD+ is our next product up for review. As our second pick, this supplement provides a 600mg daily serving of Nicotinamide Riboside Hydrogen Malate, equivalent to about 300mg of NR, to help support cellular energy and longevity. It also includes two powerful antioxidants, Quercetin and Trans-Resveratrol, which may enhance the body’s natural defense against oxidative stress. However, it lacks both BioPerine® and Vitamin B2, two ingredients often used to improve absorption and efficiency in NAD+ boosters.
While the formula has earned it a high ranking on our chart, there are a few points worth noting. The TOPCAPAK brand is not widely recognized in the supplement industry, though they do offer a small range of health products. Unfortunately, this supplement does not display GMP certification or mention any third-party testing, which are important indicators of quality and safety. Additionally, because of its liposomal delivery format, this product is not vegan. Still, for those who don’t mind that and are focused on skin health and NAD+ support, it remains a noteworthy option. Read our full review to learn more.
Click here to read the full review
|
| |
|
Rating: OK
|
Genobbely Liposomal NAD+
Liposomal NAD+ by Genobbely is advertised to support DNA repair, healthy aging, and brain function. It features a smaller daily dose of Nicotinamide Riboside (NR) at 200mg, which is on the lower end compared to some competitors. The formula omits Vitamin B2 and Quercetin, both of which can enhance NAD+ activity, but it does include Trans-Resveratrol and a serving of liposomal NAD+ for improved absorption. This supplement is also free from soy and dairy, though it is not vegan due to its liposomal composition.
Genobbely is not a widely recognized name in the supplement industry, and we were unable to locate any other products from this manufacturer. There are also no visible indications of GMP certification or third-party testing, which makes it difficult to verify production quality. That said, the inclusion of both NR and Trans-Resveratrol helps this formula stand out, earning it our number 3 spot on the list. Continue reading our full review to see what this product has to offer.
Click here to read the full review
|
